MK-677 (Ibutamoren)
Orally active, non-peptide growth hormone secretagogue studied for sustained elevation of GH and IGF-1 levels.
Research Areas
Scientific Background
MK-677 (Ibutamoren) is a non-peptide, orally bioavailable ghrelin receptor agonist. Unlike injectable secretagogues, it mimics ghrelin's action on the GHS-R1a receptor to increase GH and IGF-1 in a sustained manner, and has been widely studied in clinical research settings for its effects on body composition and bone metabolism.
Purity & Provenance
Why quality matters for research validity
MK-677 is a non-peptide small molecule (C27H36N4O5S). Research-grade material should be verified ≥98% purity via HPLC.
Areas of Investigation
Laboratory Information
Technical specifications for research settings
This compound is intended for qualified scientific research only. Not for human or veterinary use. Not for diagnostic or therapeutic applications. Researchers must comply with all applicable regulations in their jurisdiction.
Store at room temperature, away from light and moisture.
Lyophilized powder
>98% by HPLC
Soluble in DMSO; limited water solubility
Orally active in research models. For in vitro and preclinical research.
Deepen Your Research
Published literature and clinical trial registries
Published Literature
Nass et al. (2008, Annals of Internal Medicine) studied MK-677 in healthy older adults, reporting sustained increases in GH and IGF-1 to levels seen in young adults over 12 months. Murphy et al. examined its effects on nitrogen balance and bone turnover.
Regulatory Classification
MK-677 has been studied in clinical trials but is not FDA-approved. Available for qualified research purposes only.
Important Research Notice
This information is compiled from scientific literature for educational purposes only. This website does not sell, distribute, or recommend any compounds for human use. All compounds discussed are for qualified research purposes only.