MOTS-c
Mitochondrial-derived peptide studied for its role in metabolic regulation, insulin sensitivity, and exercise physiology.
Research Areas
Scientific Background
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA region. It is a mitochondrial-derived peptide that regulates metabolic homeostasis by activating the AMPK pathway and translocating to the nucleus under metabolic stress to influence gene expression related to metabolism.
Purity & Provenance
Why quality matters for research validity
MOTS-c is a 16-amino-acid mitochondrial-derived peptide. Verify HPLC ≥98% purity and sequence confirmation.
Areas of Investigation
Laboratory Information
Technical specifications for research settings
This compound is intended for qualified scientific research only. Not for human or veterinary use. Not for diagnostic or therapeutic applications. Researchers must comply with all applicable regulations in their jurisdiction.
Store lyophilized at -20°C. Protect from light.
Lyophilized powder
>98% by HPLC
Soluble in water and saline
For in vitro mitochondrial and metabolic research.
Deepen Your Research
Published literature and clinical trial registries
Published Literature
Lee et al. (2015, Cell Metabolism) identified MOTS-c as a regulator of insulin sensitivity and metabolic homeostasis, demonstrating that it activates AMPK and improves metabolic flexibility in preclinical models. Reynolds et al. explored its nuclear translocation during metabolic stress.
Regulatory Classification
MOTS-c is a research compound not approved by the FDA. Available for qualified research purposes only.
Important Research Notice
This information is compiled from scientific literature for educational purposes only. This website does not sell, distribute, or recommend any compounds for human use. All compounds discussed are for qualified research purposes only.